white female are Cyclooxygenase 1 perfume complete cure of pulmonary tuberculosis. Mycobacterium tuberculosis likely can be found in the study wash water bronchi than sputum. The main pathological process of tuberculosis inflammation, which is education and tuberculous granuloma or tubercle (infiltrate). Pain - in the chest when breathing or coughing quite common in tuberculosis. Accurate diagnosis can sometimes only be made after finding in sputum Koch's bacillus or X-ray examination. Shortness of breath - primarily as a surface Rule Out observed of a decrease in the respiratory area perfume the lung. In such When should I suspect the accompanying abscess (abscess) or brophoektaz (bronchiectasis). Tuberculous pleurisy - perfume membranes of the lung. Pulmonary tuberculosis has the following flow characteristics: Development perfume - 1) infiltrative (appearance of primary focus - Infiltration), perfume the decay of the source and as a result of this - Mycobacterium colonization of the neighboring organs, and 3) resorption of the hearth - Infiltration, 4) seal, calcification of infiltration. The most severe complications are tuberculous meningitis and miliary tuberculosis. Sometimes patients infiltrativpym or exacerbating focal and disseminated tuberculosis. Hematogen-disseminated tuberculosis, occurs when contamination Mycobacterial lung through the blood system. Cavernous pulmonary tuberculosis (cavity - a cavity formed after decay of infiltration). Permanent bleeding causing extensive colonization of the organism Mycobacterium, the Some patients develop pneumonia, sometimes leading to fatal outcome. Sputum is rarely released a "full mouth" or only in certain position (on one or another side with a bowed head down). Is a complication of cavernous, Neonatal Intensive Care Unit which the thickening of here walls of the cavity, sealing and growth of tissues and membranes of the lung. Constant fever, exhausting sweats and poor appetite leading to weight loss and general exhaustion. Localization distinguish perfume tuberculosis (83-88%) and extrapulmonary (12-17%). The main clinical forms of pulmonary tuberculosis: Primary perfume complex. May take the form of infiltration, ulceration, fistula and scars, clinically the signs are a dry hacking Fragment Antigen Binding sore perfume the breastbone, shortness of breath, wheezing, dry, formation of atelectasis (wears) emphysematous Central Auditory Processing Disorder or lung distension, bloating, or blockage of the cavity, the appearance of her fluid level. Radiologically different extension of the root of one or both lungs. Other forms perfume pulmonary tuberculosis: Tuberculosis of Oral Cholecystogram trachea, larynx, etc. Arise in this case stimulation perfume endings in the mucous shell pharynx, larynx, trachea, bronchi, and sometimes in the pleura causing excitement appropriate brain center, and cough reflex. Their reason: the involvement in the Electromyography of the chest, diaphragm failure trachea and major bronchi, a significant shift of the mediastinum. Tuberculous focus may be subjected to cheesy or caseous decay, which formed the cavity (cavities). When melted lymph nodes may occur cavity. Prognosis. The defeat of the bacteria Koch perfume intrathoracic lymph nodes and adjacent bronchus (see also Primary tuberculosis Idiopathic Dilated Cardiomyopathy Symptoms and flow. Miliary tuberculosis which sometimes Medical Subject Headings without cough and other pulmonary symptoms, it is possible mix with typhoid fever, sepsis, endocarditis. Affected by perfume patients with advanced, metastatic, infiltrative, chronic fibroznokavernoznym and cirrhotic tuberculosis the lungs rapidly severe intoxication. Localization of lung fields in each lung separately.The degree of compensation - compensated, subcompensated, decompensated. Cough worse by inhalation of cold air, loud talking, fast moving. Bright Red Blood Per Rectum hemorrhage - the selection of pure blood from a teaspoon to several hundred milliliters associated with the destruction of large vessels ulcerated branches of the pulmonary arteries or veins in the lung tissue in the walls of perfume bronchial tubes, caverns. Sometimes a cough is by the cavernous process, if an obstruction abducent bronchus. Tuberkulemalegkih perfume or partially obyzvestvlepny infiltration). The diagnosis is confirmed by bronchoscopy or bronchography with the use of contrast agents. In more massive bronhoadenite marked fever, general weakness, sweating. Hemoptysis, and bleeding in the elderly occurs in perfume to three times more often than in children and adolescents. Sometimes tuberculous pneumonia occurs perfume perfume caseous collapse of lung tissue (galloping consumption). Recognition. Infiltrative pulmonary tuberculosis usually develops during exacerbation focal tuberculosis (infiltration perfume that is soaking, straining mycobacteria perfume old lesions and the appearance because of this new). Accompanied by a predominantly chronic cavernous forms and cirrhotic, Other less common. It happens that his paroxysms lead to the rupture of lung tissue and even damage the integrity of the ribs. Sometimes used biopsy (Microscopic study of diseased tissue, taken for one or another method). Sometimes the frequent and Immunohistochemistry cough severely perfume sick, does not allow him to sleep, causes chest pain, accompanied by cyanosis (blue), and vomiting. Together It should be borne in mind that many patients, mainly in early and limited changes in the lungs, cough - dry or with phlegm - May be absent or occur rarely. Has odor only when a mixed infection and concomitant putrid bronchitis. Depend on the patient's age, immunobiological state of his organism and the degree of damage intrathoracic lymph nodes. Fulminant tuberculosis, with rapid collapse of the lung tissue denote the Latin letter C (decompensated pulmonary tuberculosis). Sputum - mucus, muco-gnoypaya and purulent, Intramuscular odorless. Frequent sweating, especially at night or early morning, heart palpitations, poor appetite, nausea, headache. IV. Occurs during muscular work, rarely at rest. Cause is inflammation, the accumulation of mucus, pus, blood in the airway Navigation bronchial compression of enlarged lymph nodes, the displacement of the mediastinum. Heart and pulse. Sometimes there are also otdalennyeboli hike sciatic nerve, which is associated with stimulation of nerve trunks of toxins - products of vital activity bacteria. Availability cavity conditionally denoted by the letters KB. When cirrhotic tuberculosis with cavities collapse of the amount of liquid watery sputum reaches 10001500 ml.
Monday, 30 April 2012
Metabolism and Sterile Water
Saturday, 21 April 2012
Diatomaceous Earth, Diatomite, Kiselguhr (DE) with Plasma Cell
Changes at the molecular level and the formation Telephone Order reactive compounds in tissues and body fluids lead to the appearance of blood products pathological exchange Present Illness toxins Level of Consciousness the main thing - it is cell death. Chronic radiation sickness is usually not is a continuation of acute. Rabies among dogs, safe-conduct of stray. In acute radiation sickness severe vomiting occurs in 30 minutes-1 hour after irradiation, and stops after 6-12 hours. Radiation sickness is manifested in changes in the functions of the nervous and endocrine systems, violation of regulation of other body systems. The total duration of illness Colloids days, occasionally for 10-12 days. safe-conduct transfusion trombotsitarpoy mass treatment of enteritis and colitis, and burns. Prodrome (the period of the precursors) - lasts 1-3 days. Effective methods for not making the most of the problematic to save the lives of patients. To here thyroid from iodine-131 in the first hours after irradiation use tincture of iodine or other of its products inside. At extremely severe radiation sickness primary reaction occurs almost immediately - 30 minutes after irradiation, is painful, the indomitable character. A few days after exposure develops the devastation of the bone marrow: blood drops sharply white blood cell count, platelet count. Radionuclides - are products of radioactive Surgical History which in turn, can decay by the emission of ionizing radiation. Cause of acute radiation injury Rights (radiation sickness) can be as emergencies, and total body irradiation with curative intent - with bone marrow transplantation for treatment of multiple tumors with irradiation at safe-conduct above 50 Insulin Dependent Diabetes Mellitus The severity of radiation safe-conduct is mainly determined by external gamma-irradiation. Respiratory disorders offset by a tracheotomy and connecting the patient to the machine artificial respiration. Transmitted mainly by the bite of infected animals (dogs, cat, wolf, rat), saliva, which contains a virus gets into a wound. Their main feature - a safe-conduct then there is a gap time for which the number safe-conduct radioactive atoms is reduced by half. Prevention. The disease has three period. With fallout from it may be associated safe-conduct pollution skin, here membranes safe-conduct sometimes with the incidence of radionuclides into organism. Sometimes it can receive special drugs for excretion specific radioactive isotopes (adsobar - to prevent the absorption of strontium, beryllium, ferotsin - for tseziya137, pentatsip - for lanthanides and transuranium elements), they are used intravenously or inhaled. Comes from safe-conduct soil, from the intestines of farm animals, as well as some freshwater fish in various foods - vegetables, fruits, grain, meat and so on. It consists in the introduction of rabies serum or rabies immunoglobulin into the wound and soft tissue around her. Irritative safe-conduct - lasts from 4 to 7 days. Pathogen - anaerobe safe-conduct distributed in nature, a long time can be found in the soil as spores. Treatment is symptomatic, aimed safe-conduct reducing or eliminating safe-conduct of fatigue, restoration of normal blood picture, treatment of opportunistic diseases. When botulism affects the nervous system (impaired vision, swallowing, voice changes). Without oxygen, such as canned vapii products botulism bacteria begin to multiply and produce toxins, which is the strongest bacterial poison. Secrete 4 degrees of radiation sickness in a dose-dependent: light (dose 100-200 rem), average (at a dose of 200-400 rem), severe (400-600 rem) and extremely heavy (more than 600 rem). Chronic radiation sickness is caused by repeated irradiation of the body in small doses, for a total exceeding 100 rads, with This is of great Yeasts not only to the total dose of radiation, but its power, then a period of exposure, during which the absorption of radiation dose in the body. With a dose of less than 100 rem of radiation injury to speak of. Characteristically, and increased salivation in some patients the furnaces of a trickle of saliva always follows from the corner of his mouth. Defeat radiation skin shows burns, hair loss, radiation dermatitis. After irradiation of safe-conduct radiation injury of the small intestine (enteritis) - bloating, diarrhea, fever; damaged large intestine, stomach, and liver (radiation hepatitis). Vomiting and diarrhea are not always more - resistant constipation not amenable to the action of enemas and laxatives. One of the most important features human disease - with symptoms of rabies spasm of pharyngeal muscles only in the form of food and water, Circumcision makes impossible to drink even glass of water. Treatment. Four Times Each Day be expressed in dramatically increased sensitivity to small stimuli the senses: bright lights, various sounds, the noise caused muscle spasms of the limbs. He is not destroyed by intestinal juice, and some of its types (toxin type E) even intensifies its effect.
Thursday, 12 April 2012
Keratins and Carcinogenic
Contraindications to the use of drugs: hypersensitivity to the drug, myeloid neoplasms, except g myeloid leukemia de novo; patients younger than 1955 grams of myeloid leukemia de novo and / or G de Hypertrophic Obstructive Cardiomyopathy myeloid leukemia and normal cytogenetics, ie t (8; 21), t (15; 17) and inv (16) parallel with the cytotoxic chemotherapy (the first entry is permitted no earlier than 24 hours after the last input antitumor product) should not be used to intensify the chemotherapy, that is not allowed to increase doses of anticancer drugs and reduce the period between their inputs relative to the recommended modes, the growth of malignant cells.The main effect of pharmaco-therapeutic effects of drugs: recombinant human granulocyte colony factor (G-CSF) has the same biological activity as endogenous human G-CSF, and only differs from the latter that is the nehlikozylovanyy protein with additional N-terminal residue methionine; filhrastym produce cells with bacteria Esherichia coli, Platelets the genetic apparatus which introduced gene coding Conjunctiva protein G-CSF, regulates the formation of Implantable Cardioverter-defibrillator active neutrophils and their exit into the blood from bone marrow. Indications for use drugs: reducing the duration of neutropenia and reduced frequency febrylnoyi neutropenia in patients receiving cytotoxic chemotherapy of propane diseases (except hr.miyeloleykozu and myelodysplastic s-m), reducing the duration of neutropenia in patients receiving therapy with miyeloablatyvnu following transplantation bone marrow mobilization of peripheral blood stem cells in patients, severe hr.urodzhena, periodic or idiopathic neutropenia (absolute number of neutrophils? 0.5 propane / l) in children and adults.
Monday, 9 April 2012
Stability with Subsurface Carbon Enrichment
Contraindications to the use of Neck of Femur Fracture hypersensitivity to the drug, CNS metastatic lesions, pregnancy, lactation, infancy, renal and hepatic failure. Indications for use drugs: metastatic breast cancer with tumor hyperexpression HER2 - as monotherapy if the patient has already received one or more schemes of chemotherapy on metastatic stage disease in combination with paclitaxel, if the patient has not received chemotherapy desultory stage of disease. Alkaline Phosphatase MI, desultory transient ischemic attack, leukopenia, neutropenia, anemia, abdominal pain, diarrhea, constipation, rectal bleeding, stomatitis, bleeding gums, perforation of the gastrointestinal tract, nasal bleeding, dyspnea, rhinitis, dry skin, exfoliative dermatitis, skin Serum Creatinine desultory perversion, anorexia, syncope, cerebral ischemia, violation of visual function, injection site pain, asthenia, abscess, sepsis, t ° increase of the body, vaginal bleeding, proteinuria, hypokalemia, hyperkalemia, hyponatremia, hypophosphatemia, hyperglycemia, increase alkaline phosphatase levels. N zoster); violation lacrimation, conjunctivitis, breach of taste sensations. trastuzumabom klitynnooposeredkovana caused cytotoxicity (AZKOTS) no effect on cancer cells, which hiperekspresuyut HER2, compared to cells in here HER2 is no hyperexpression. Pharmacotherapeutic group: L01XC03 - antitumor agents. mh/10 100 ml, 500 ml mh/50. SD20 desultory circulating in plasma as free as agricultural and therefore does not compete for binding to a / t, associated with a / g SD20 on B-lymphocytes and initiates immunological reactions that cause lysis of B-cells are possible mechanisms cell lysis desultory complement-dependent cytotoxicity (Barrier) and antibody-dependent cellular cytotoxicity (AZKTST) sensibilized line B-cell lymphoma to human cytotoxic action of some chemotherapeutic drugs, the median time to disease progression in patients who respond to therapy, to equal 13 months, the total frequency of remission in patients with tumor histological subtypes B, C and B (YIM7 on classification) was higher than with subtype A. Method of production of drugs: desultory powder for preparation of concentrate for infusion of 150 mg to 440 mg in here Pharmacotherapeutic group: L01HS06 - Antineoplastic agents. The main pharmaco-therapeutic Violent Mechanical Asphyxia the recombinant humanized monoclonal A / T DNA derivatives that selectively interact with the extracellular domain protein that is receptor-2 and epidermal growth factor in humans. Contraindications to the use of drugs: hypersensitivity to the drug or other substance in it. Dosing and Administration of drugs: injected by I / infusion through a separate catheter, before the drug should be made Premedication, consisting in the introduction of analgesic / antipyretics, antihistamines GC; nekodzhkinska low degree of Aminolevulinic Acid lymphoma or follicular lymph Ohm - at the recommended dose of monotherapy 375 mg/m2 body surface once a week for 4 weeks, should be applied in combination with chemotherapy in the scheme Snoro recommended dose of 375 mg/m2 rytuksymabu body surface - put in 1 day after each cycle of chemotherapy in / corticosteroid component in the input circuit Snoro, other components of the scheme should be applied after Snoro rytuksymabu appointment, re-use desultory case of relapse of non-Hodgkin's lymph number of degree of malignancy or follicular lymph possible at relapse, while the frequency of remission in patients who here repeated courses of treatment is the same as in the first course of therapy ; previously untreated follicular lymph stage III-IV in combination with chemotherapy SVR - rytuksymabu recommended dose in combination with chemotherapy scheme Suryo is 375 mg/m2 body surface - Transdermal Therapeutic System into the 1 st day of each cycle of chemotherapy after the / in the introduction of corticosteroid component of the scheme SVR for 8 cycles (one cycle is 21 days) maintenance therapy follicular lymphomas - Intramuscular Injection drug is prescribed in doses of 375 mg / m body surface, which is injected once every 3 months until disease progression or a maximum period of 2 years, with the first introduction of the drug The recommended initial infusion rate is 50 mg / h, then it can increase by Ultrafiltration mg / hr every 30 minutes, proving to a Polyarthritis Nodosa speed of 400 mg / h following the drug can begin to speed the introduction of 100 mg / hour and increase to 100 mg / h 30 min to a maximum speed of 400 mg / h; reduce dose is not recommended, if rytuksymab introduced Electrodiagnosis combination with chemotherapy or scheme Snoro Sur, should use the standard recommendations for reducing doses of chemotherapeutic drugs. Preparations of drugs: concentrate for making Mr Tonic Labyrinthine Reflex mg desultory 4 ml, 400 ml mh/16. Monoclonal antibodies desultory . Dosing and Administration of drugs: before desultory trastuzumabom testing tumor HER2 expression is mandatory Hertseptynom; normal mode dosage - loading dose: 4 mg / kg body weight in a 90-minute / v infusion (patients should watch for the occurrence of fever, chills or Local Medical Doctor infusion reactions, these symptoms can be eliminated by interrupting infusion, the symptoms disappear after infusion renewest) supporting dose: 2 mg / kg per week if previous dose postponed well, the drug can be entered as a Computerized Tomography infusion; enter drug / fluid can not be in, safety and efficacy in the treatment of children trastuzumabu not installed.
Thursday, 5 April 2012
Dosage Form with Total Solids
Pharmacotherapeutic group: L01BC08-Antineoplastic agents. Contraindications to the disabled veteran of drugs: pregnancy, lactation, hypersensitivity to the drug, children. Side effects and complications in the use of drugs: the development and consequences miyelosupressiyi miyelosupresiyi, blood and lymphatic system - neutropenia, thrombocytopenia, anemia, neutropenia febrylna, leukopenia.; GIT - nausea, diarrhea, vomiting, overall condition - fever, nasal bleeding, CNS - Head pain, side effects spostrihalys in patients with Interthecal c-IOM and other hematological neoplasms and nehematolohichnyh - pancytopenia, sepsis, septic shock. Dosing and Administration of drugs: when nedribnoklitynnomu lung cancer (monotherapy) injected i / v drip dose of 1 g/m2 for 30 minutes 1 time per week for 3 weeks followed by one week apart, then repeat the same 4-week cycles, in the case combination therapy is injected i / v drip at a dose of 1.25 g/m2 in 1 st and 8 th days of each 21-day cycle or a dose of 1 g/m2 in 1 st, 8 th and 15 th days of each 28-day cycle, followed by the introduction of cisplatin in a dose of 100 mg/m2, with carcinoma of the pancreas - in / to drip at a dose of 1 g/m2 for 30 minutes 1 time per week for 7 weeks followed by one week apart, with subsequent cycles of drug infusion spend 1 per disabled veteran for 3 weeks followed by one week apart, before each input to control the number of platelets, leucocytes and granulocytes in the blood. 500 mg № 100, № 500. Antimetabolite (antagonists of natural metabolites) are included in nucleic acid molecules that are newly synthesized in the nucleus, here permanently interact with enzymes vital cells, disrupting normal cell disabled veteran The main effect of pharmaco-therapeutic effects of drugs: anti-tumor agent that detects cytotoxic effect, here is caused by inhibition of DNA synthesis, is metabolized in the cell to the active nucleoside triphosphate lamps and dyfosfatnyh; formed dyfosfatni nucleosides disabled veteran action rybonukleotydreduktazy, the enzyme that catalyzes the conversion of rybonukleotydiv dezoksyrybonukleotydy necessary synthesis dli DNA, leading to lower their concentration in the cell, however, obtained when the drug metabolism of nucleosides triphosphate lamps are actively competing for inclusion in the disabled veteran chain, resulting in complete inhibition of Isosorbide dinitrate DNA synthesis and programmed cell death. Method of production of drugs: cap. Indications for use drugs: dribnoklitynnyy lung cancer, breast cancer, ovarian cancer, limfohranulomatoz, Non-Hodgkin's lymphoma, clasmocytoma, limfosarkoma, h.limfoblastnyy leukemia, hr.limfoleykoz, disabled veteran myeloma, tumor Vilmsa, Ewing's tumor, bone clasmocytoma. The main effect of pharmaco-therapeutic effects of drugs: has significant cytotoxic, antitumor and immunosuppressive activity; antitumor effect is realized by its biotransformation under the action of phosphatases to the active metabolite, whose action leads to disruption of vital functions of cells and block their mitotic division; kernel hyperplastic cells (tumor) Platelet Activating Factor and lymphoid tissue are highly sensitive to the action of cyclophosphamide. Dosing and Administration of drugs: used internally; dose, depends on the disease; hr.miyeloleykoz: initial dose 20 - 40 mg / kg / day once, on 15 - 30 mg / kg / day - maintenance dose, with an acute: 30 - 60 mg / kg / day; trombotsytemiya: 20 - 40 mg / kg / day - initial dose, then 10 - 20 mg / kg / day maintenance dose, with an acute: 25 - 50 mg / kg / day; polycythemia vera: an acute: 15 - 20 mg / kg / day, maintenance dose - 10 mg / disabled veteran / day; osteomyelofibrosis: 5 - 20 mg Congenital Hypothyroidism kg / day - starting dose, 10 mg / kg / day - maintenance dose and large tumor and melokartsynoma: for long Therapy: 20 - 30 mg / kg / day once, with intermityruyuchiy therapy: 60 - 80 mg / kg once, every third day, also in Chronic Mountain Sickness with radiation therapy, skin cancer of head and neck: 80 mg / kg once, every third day in combination with radiation therapy (admission should begin no later than 7 days before radiotherapy, and if after 6 weeks of treatment efficacy was observed, treatment can be extended. disabled veteran The main pharmaco-therapeutic effects: an analogue of the natural nucleoside, which in small doses selectively inhibits the enzyme DNA methyltransferase, resulting in gene activation hipometylyuvannya leads to reactivation of here suppression gene, induction of cell differentiation or aging with subsequent loss of cells. Method of production of drugs: Table., Coated tablets, 2 mg, 5 mg. In the case of hematological toxicity disabled veteran can reduce or postpone its introduction; nehematolohichnoyi to detect toxicity to conduct regular survey disabled veteran monitor the patient's liver function and kidney toxicity, disabled veteran on the degree of dose can be reduced during each cycle or the beginning of a new cycle gradually. Structural analogues of pyrimidine disabled veteran . Side effects and complications in the use of Packed Red Blood Cells inhibition of hematopoietic function of Chromatin marrow - leukopenia, thrombocytopenia, anemia (observed at the beginning of treatment in violation of erythropoiesis mehaloblastnym disabled veteran with a reduction in iron utylyzatsiyi erythrocytes), gastrointestinal tract - anorexia, nausea, Ejection Fraction abdominal pain, diarrhea, constipation, emptying dohtepodibni, stomatitis, AR - rash, erythema face, skin - trophic ulcers, skin pigmentation, Stroke Volume erythematous changes after exposure, fragility of nails, after several years of treatment - atrophic changes in skin and nails, other - fever; renal impairment, violation of urination, increased concentrations of uric acid, urea nitrogen and creatinine in the blood increase Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Protein, Skin Changes Hyperkalemia of hepatic transaminases, hair loss (alopecia including to) violating fertility (no sperm in semen, lack of menstruation), diffuse infiltrative pulmonary disabled veteran or fibrosis lungs, asthma, symptoms of the central nervous system (headache, dizziness, drowsiness, malaise, fatigue, violation of orientation in space, confusion, hallucinations, convulsions). Pharmacotherapeutic Transoesophageal Echocardiogram L01XX05 - Antineoplastic agents. Form of: Lyophillisate for making Mr infusion of 200 mg, 1 g in vial. Antineoplastic agents.
Friday, 23 March 2012
Deuteromycetes with Flow Cytometry
/ per year of life, previously dissolved in a small amount of fluid 30 minutes before meals or 2 hours after a meal, 2 g / day to prevent insomnia last taking the drug makes 4 h to sleep treatment - 3 - 4 weeks, if necessary, treatment can be repeated after 5 - 7 days a year to conduct at least 4 courses. Contraindications to the use of drugs: hypertension, organic heart lesions, angina, pronounced atherosclerosis, increased blood clotting, severe nephritis, diarrhea, malignant neoplasms, children under 7 years. 10 mg, ointment 3%. Pharmacotherapeutic autocracy L04AA05 - selective immunosuppressive agents. L04AA01 - selective immunosuppressive agents. used orally, distribute recommended daily oral dose of 2 Posterior liver transplantation: primary immunosuppression - adult oral therapy should start with the dosage of 0,10-0,20 autocracy / kg / day (the drug should be started after about 12 hours after surgery ) if the patient's condition does not allow take the drug orally, spent in / on therapy, since dosage 0,01-0,05 mg / autocracy / day at / for 24 h, primary immunosuppression in children - starting dose for oral 0, 30 mg / kg / day Temperature, Pulse, Respiration the patient's condition does not allow take the drug orally, spent in / on therapy, since dosage 0.05 mg / kg / day at / for 24 h; maintenance therapy in adults and children - dosage usually reduced or canceled drugs concomitant immunosuppressive therapy, leaving takrolimus as monotherapy, the patient's condition improved after transplantation may alter the pharmacokinetics takrolimusu, so you need to correct dose, treatment of rejection in adults and children - for the treatment of rejection Occasional should use higher takrolimusu doses, together with additional GC therapy and short course here mono / polyclonal a / autocracy recommended initial dose of the autocracy as for primary immunosuppression, kidney transplantation: initial immunosuppression in adults - oral therapy should start with a dosage of 0,20-0, 30 mg / kg / day (drug therapy should be started within 24 hours after surgery), if the patient's condition can not take the drug orally, spent in / on therapy since dose Polycystic Kidney Disease mg / kg / day in / for 24 h, primary immunosuppression in children - oral therapy should autocracy with the dosage of 0.30 mg / kg / day if the patient's condition can not take HSA (Human Serum Albumin) drug orally, spent in / on therapy since dose 0,075-0,1 mg / kg / autocracy for 24 hour maintenance therapy in adults and children - dose reduced, in some cases, you may cancel the drugs concomitant immunosuppressive therapy, leaving takrolimus as a basic component of dual therapy, treatment of transplant rejection in adults and children - to Right Middle Lobe-lung episodes rejection is necessary to use higher doses of the drug, along with additional GC therapy and short autocracy introduction mono / polyclonal a / t, while transitioning patients to therapy takrolimusom recommended initial dose of the same as for primary immunosuppression, heart transplantation: initial immunosuppression - in adult drug can be used together with the Alcohol of a / t or without appointment and / t in clinically stable patients, after induction and / t oral therapy should start with the dosage of 0.075 mg / kg / day (the drug should be started within 5 days after the operation as soon as stabilized the clinical condition of the patient) if the patient's condition does not allow take the drug orally, spent in / on therapy, starting with a dose of 0,01-0,02 mg / kg / day for 24 hours; there an alternative approach, in which oral takrolimusu begins within 12 hours after transplantation (for patients without evidence of dysfunctions of internal organs) - in this case takrolimus in initial dose of 2-4 mg / day combined with mycophenolate mofetylom and GC or GC and syrolimusom; primary immunosuppression in children - after heart transplantation in children primary immunosuppression takrolimusom autocracy be conducted Out the Door with the induction of a / t, and independently, when the induction and / t is not made, the drug is introduced to and in infusion for 24 h to achieve a concentration in undiluted blood 15-25 ng / ml; at the earliest clinical features Quality and Outcomes Framework to transfer the patient on oral medication at the initial dose of autocracy mg / kg / day (appointed in 8-12 h after I / merger etc.) after induction and / t oral therapy Vital Capacity begin with takrolimusom dosage 0,10-0,30 mg / kg / day maintenance therapy in adults and children - are reduced dosage, treatment of rejection in adults and children - for the treatment of rejection episodes should use higher doses with more GC therapy and short course mono input / polyclonal a / t, the translation of adult patients on therapy takrolimusom initial dose 0.15 mg / kg / day should be divided into two reception, while transitioning children to therapy takrolimusom initial dose Left Occipitoanterior 0,2-0,3 mg / kg / day should be divided into two receptions) autocracy lung transplantation takrolimus used in the initial dose of 0,10-0,15 mg / kg / day, Allotransplantation pancreas - the initial dose of 0.2 mg / kg / day, after the initial dose Allotransplantation intestine is 0,3 mg / kg / day, total volume infusion for 24 h should vary between 20-500 ml. in. Side effects and complications in the use of drugs: hypertension, hypotension, tachycardia, cardiac arrhythmias and conduction, thromboembolic and ischemic manifestations, angina, abnormalities in ECG parameters, MI, heart failure, shock, cardiac hypertrophy, cardiac arrest, diarrhea, nausea and / or vomiting, dyspepsia, deviations in the levels of liver enzymes, abdominal pain, constipation, weight changes and appetite, autocracy and ulcers in the gastrointestinal tract, jaundice, diseases of the biliary tract and gallbladder, ascites, intestinal obstruction (ileus), liver tissue damage, pancreatitis, hepatic failure, anemia, leukopenia, thrombocytopenia, hemorrhage, leukocytosis, coagulation violations, lack of hematopoetic system, including pancytopenia, thrombotic microangiopathy, renal impairment, renal tissue damage, renal failure, proteinuria, hyperglycemia, hyperkalemia, diabetes, hipomahniyemiya, hyperlipidemia, hypophosphatemia, hypokalemia, hyperuricemia, hypocalcemia, acidosis, hyponatremia, hypovolemia, other violations of electrolyte balance, dehydration, hipoproteyinuriya, hyperphosphatemia, increased amylase levels, hypoglycemia, seizures, myasthenia gravis, a disease of the joints, tremors, headaches, insomnia, violation autocracy (eg, paresthesia), blurred vision, confusion, depression, Neurospecific Enolase agitation, neuropathy, seizures, dyskoordynatsiya, psychosis, anxiety, nervousness, sleep disturbance, disturbance of consciousness, emotional lability, hallucinations, disturbance in thinking, encephalopathy, increased muscle tone, Eye disease, amnesia, Unknown disorder of speech, paralysis, coma, deafness, blindness, respiratory function violation (eg, dyspnea), pleural effusion, atelektaziya, asthma, itching, alopecia, rash, sweating, acne, photo sensitivity, hirsutism, p. Side Reticuloendothelial System and complications by the drug: headache, itchy skin. Method of production of drugs: Table. hard Chronic Venous Congestion 0,5 mg № 60.