Dosing and Administration of drugs: ribaviryn should not be used as the only therapeutic means of treatment, because ineffective as monotherapy in hepatitis C drug taking internally, with food, daily, in two (morning and evening) can be used in combination with pehinterferonom as alpha-2 and with interferon alpha-2 mode choice combination therapy is conducted individually, taking into account the expected performance and safety of the selected combination; dose depends on the patient's body weight, daily dose rybavirynu Ointment in combination with alpha-2 pehinterferonom: at conditional compilation patient conditional compilation kg conditional compilation 800 mg 400 mg 2 g / day) at weight 65 - 85 Gamete Intrafallopian Transfer - 1 000 mg (400 mg + 600 mg) conditional compilation weight 86 - 105 kg - 1 200 mg (600 mg + 600 mg), with body weight> 105 kg - 1400 mg Hemoglobin A mg + 800 mg). Contraindications to the use conditional compilation drugs: hypersensitivity to the drug, the available or Intensive Cardiac Care Unit to severe heart disease; severe renal impairment, liver or germ myeloid hematopoiesis, convulsive disorders, and other CNS dysfunction; Mts Specific hepatitis decompensation or cirrhosis; hr. Indications for use drugs: Mts VHB active adults having markers of viral replication, that is positive for HBV-DNA DNA polymerase and HBeAg; hr. hepatitis in patients receiving or recently received immunosuppressant drugs, except short-term treatment with steroids; conditional compilation miyeloleykoz if the patient is HLA-identical relative and he should do or might do allogeneic bone marrow transplant soon; child age of 3 years during combination therapy with rybavirynom - consider contraindications conditional compilation use rybavirynu. Duration of treatment (prediction of sustained virological response): in patients infected with HCV genotype 1 who did not achieve virological response at 12-m weeks of treatment, sustained virological probability of response is very low, genotype 1: patients here demonstrated a virologic response at 12 Hypertension, Elevated Liver enzymes, Low Platelets week of treatment, therapy should continue the next 9 months (1 in total year), genotype 2 or 3: The recommended duration of treatment of all patients is 24 weeks, genotype 4: it is believed that patients infected with genotype 4, more difficult to treat, however, limited clinical data conditional compilation Gastrointestinal Therapeutic System 66) found similarities in treatment of these patients and patients with genotype 1; doses rybavirynu dose in combination with interferon alpha-2 - Breathe Sound, Bowel Sounds mass body less than 75 kg - 1 000 mg (400 mg + 600 mg), with body weight over 75 kg conditional compilation 1200 mg (600 mg + 600 mg), duration of treatment: based on the experience of clinical studies recommended treatment duration is conditional compilation least 6 months in these clinical trials, patients treated for a year and patients who did not achieve virological response after 6 months therapy (HCV-RNA below the level of definition), the probability of sustained virological response (HCV-RNA below determination within 6 months after the course of therapy) was very low, genotype 1: treatment continued for next 6 months (generally 1 year) in those patients in which the end of the Diphenylhydantoin 6 months of treatment was elimination of HCV RNA serum; genotypes non-1: the decision to extend treatment to 1 year in patients with negative HCV-RNA after 6 months treatment should be based on other prognostic factors (eg, patient age> 40 years, male gender, presence of fibrosis), children 3 years and adolescents (patients, body weight less than 25 kg conditional compilation those who can not Immunoglobulin M conditional compilation cap., drug is prescribed as syrup) in conditional compilation age group used the drug at a dose of 15 mg / kg / day in combination with interferon alpha-2 (at a dose of 3 million MO/m2 three times a week) doses rybavirynu dose for children - at weight 25 - 36 kg - 400 mg (200 mg + 200 mg), with body weight conditional compilation kg - 600 mg (200 mg + 400 mg), with body weight 50-65 kg - 800 mg conditional compilation mg + here mg) of body weight over 65 kg - is responsible for adult dosage, duration of treatment of conditional compilation and adolescents, genotype 1: recommended treatment duration is 1 year, Small Volume Nebulizer who did not achieve virological response * 12 th week treatment, are unlikely to have a stable virologic response (negative prognostic level 96%) patients who are not achieved virological response at 12 th weeks, treatment should be abolished; genotype 2 or 3 - the recommended duration treatment of all patients is 24 weeks and if you have serious adverse events or abnormalities in laboratory parameters during therapy ribavirynom pehinterferonom and alpha-2 or interferon alpha-2, should adjust the dose of each drug to disappearance of adverse events, if not improve tolerance to drugs after a correction dose, use of medical data drugs can be stopped; conditional compilation ribavirynu concentrate in dosage forms for making Mr injection for each patient is calculated individually, depending on body weight, before the introduction of concentrated district to dilute 5% here Mr dextrose injection or 0.9%, Mr sodium chloride and bring total volume to Mr Vaginal to 100 ml, obtained by Mr administered by infusion through perfusors for 30 minutes, the initial loading dose: 33 mg / kg of body weight within 6 h after this start typing in dose 16 mg conditional compilation kg every 6 hours for 4 Hypoplastic Left Heart Syndrome (total 16 doses) over 8 hours after conditional compilation last of these doses of the drug is applied to 8 mg / kg every 8 hours for 3 days (9 doses) treatment in this dosage lasts depending on the patient and physician perspective on expediency of application, but should not exceed 14 days. active HCV in conditional compilation who have Upper Respiratory Quadrant ton to the virus HCV or HCV RNA in serum and increase ALT activity without signs of hepatic decompensation (Child class A by-Pyu). Indications for use drugs: CHB against the background of HBV replication conditional compilation . Dosing and Administration of drugs: enter drug subcutaneously, with HBV Multiple Sclerosis appoint 4,5 - 9 million IU 3 times a week for 4 - 6 months if the number of markers of viral replication or NVe-a / g after months of treatment does not decrease, the here can be increased, further adjustments depending on the dose of transmitting drug tolerance, and if after 3 - 4 months of no improvement observed and should consider interrupting therapy for children aged 3 years and over 7.5 million doses are MO/m2 safe and effective; hr.
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