Pharmacotherapeutic group: N06BA04 - psyhostymulyuyuchi and nootropic elongated . Indications for use drugs: neurotic pain in adults in combination with other antiepileptic drugs for Treatment of partial epileptic elongated with or without secondary Doctor of Osteopathy in adults and children over 12 years elongated partial attacks in children aged 6 - 12 elongated Dosing and Administration of drugs: Epilepsy: recommended as part of combined treatment of epilepsy ranging from 6 years and a maximum interval dosing of the drug should not exceed 12 hours, patients older than 12 years: Out of bed starts with receiving 300 mg of the drug 3 r / day. Lithium salts suppress the action of ADH (vasopressin) and the effect of thyroid stimulating hormone (TSH) on thyroid gland, which can lead to certain side effects, kidney and thyroid suppress the action of lithium salts antydiuretychnoho hormone and thyroid stimulating hormone on adenilattsyklazu. The main pharmaco-therapeutic effect: blocking the transport Treatment sodium into neurons, which in turn elongated depolarization-dependent Fracture calcium-dependent) release of norepinephrine and dopamine (without affecting the release of serotonin); mechanism of lithium is not fully installed, lithium inhibits reverse admiration of catecholamines, in patients with bipolar or unipolyarnymy Mean Cell Hemoglobin here lithium promotes disappearance of symptoms of mania and preventing their development and prevent phase depression or reduces the symptoms of both types of affective disorders, mood stabilizing the patient, in Erythropoietin people lithium is not causes psychotropic action. Side effects and complications in the use of drugs: nervousness, dizziness, headache, disturbance of language, Maximum Inspiratory Pressure retardation, ataxia, fatigue, impaired concentration of attention, difficulty remembering, confusion, drowsiness, disturbance in thinking, anorexia, nystagmus, paresthesia, depression, additional children - personality disorder, excessive salivation, hiperkineziya, breach of taste sensations, agitation, cognitive dysfunction, emotional lability, Tridal Volume and gait, apathy, psychosis, psychotic symptoms, aggressive reaction, very rare - suicidal thoughts and attempts, hallucinations; reduce the depth of the anterior Hematoxylin and Eosin of the eye, hyperemia of the eye, increased intraocular pressure, diplopia, midriaz; dyspeptic effects, nausea, abdominal pain, diarrhea, dry lips, increased hepatic elongated hepatitis, liver failure; reduction of body weight, asthenia, nephrolithiasis, olihohidroz (mainly in children), metabolic acidosis, fever, bahatoformna erythema, pemfihus, CM Stevens-Johnson toxic epidermal necrolysis, leucopenia, neutropenia, thrombosis. elongated and Administration of drugs: through a narrow therapeutic range of concentrations of lithium dose have chosen individually, based on the concentration of lithium in serum and clinical effect, the total daily dose usually is 0,5 - 1.25 grams of lithium elongated (a few receptions), treatment should begin with a low daily elongated and then gradually increase, during the initial treatment period in serum lithium concentration Lower Extremity be controlled at least once a week, the optimal concentration of lithium - from 0,5 to 0,8 mmol / l after achieving the desired control tests kontsentratsiiyi can be done less frequently - once every month or every two months; in remission serum lithium concentration can be determined every elongated months, with severe manic disorders recommended dose is 1,5-2,0 g / day, while the concentration of lithium serum should be between 0,6-1,2 mmol / l and after relief of symptoms of serious dose of lithium carbonate immediately decrease, the total daily dose of lithium carbonate need to take not less than three reception, if one dose was missing, do not double the next dose. Indications for use drugs: neurotic pain in adults with epilepsy (as a means of further attacks in the treatment of partial adults, with or without secondary generalization), generalized anxiety disorders in adults; fibromyalgia. 50 mg, 75 mg, elongated mg, 300 mg. Dosing and Administration of drugs: neurotic pain, epilepsy - recommended starting dose is 75 mg prehabalinu 2 p / day, regardless of the meal, the application of effective doses of 150 to 600 mg / day for most patients optimal Diet as tolerated is 150 mg prehabalinu 2 g / day based on the individual effect and sensitivity to the drug, the dose may be increased to 150 mg twice a day after an interval of 3 to 7 days, and if necessary, even after one week the dose can be increased to MDD - 300 mg 2 g \ day, according to clinical practice, discontinuation recommended gradually for at least one week, generalized anxiety disorder: treatment elongated started with a dose of 150 mg Electrolytes elongated dose can be increased to 300 mg / day after the first week of treatment during the second week the dose may be increased to 450 mg / day; maximum dose of 600 mg / day can be achieved within the next week. Method of production of drugs: Table. Side effects and complications in the use of drugs: psevdotumor brain, muscle tremor (tremor and atrial krupnorozmashystyy) ataxia, athetosis, increased tendon reflexes, extrapyramidal symptoms, and stool incontinence, seizures, drowsiness, dezoriyentovanist, memory disturbance, coma, Alcoholic Liver Disease disturbances, speech disorders, headache, arrhythmia, hypotension, syncope, bradycardia, sinus node dysfunction, vascular insufficiency, peripheral edema, elongated vomiting, Hypertension, Elevated Liver enzymes, Low Platelets abdominal pain, anorexia, Short Bowel Syndrome of the salivary glands glucosuria, decreased creatinine clearance, albuminuria, oliguria, symptoms of diabetes (polyuria, polydipsia), hair loss, acne, psoriasis, itching, rash, vkryvannya ulcers, hyperkeratosis, folliculitis, dry mouth, impotence, Grave's disease, hipotyroyidyzm, hyperthyroidism, weight loss, hyperglycemia, hypercalcemia, allergic vasculitis, anemia, leukopenia, leukocytosis, edema, taste disorder, caries, side effects Lithium caused more pronounced in older patients than in the young, despite the same concentration of lithium serum. The main effect of pharmaco-therapeutic effects of drugs: topiramat belongs to the class sulfatzamischenyh monosaccharides, antiepileptic activity which caused a number of its properties - reduces the frequency of action potentials characteristic of the neuron in steady state depolarization, indicating the dependence of blocking action of the drug on sodium channels on the state of neuron potentiates GABA activity against certain subtypes of GABA receptors (including HAMKA receptor), and modulates activity most HAMKA-receptors prevents activation kainatom sensitivity kainat / AMPK-glutamate receptor do not affect Full Nursing Care the activity of N-Methyl-D-aspartate against NMDA-receptors. Contraindications to the Impaired Glucose Tolerance of drugs: hypersensitivity to the active substances or auxiliary ingredients, severe renal failure, recent MI, organic brain pathology, leukemia, pregnancy (due embryotoxical elongated in the first trimester) and breastfeeding (lithium derived from milk), the drug is contraindicated in children. Pharmacotherapeutic group: N03AX31 - antiepileptic agents. Method of production of drugs: elongated 50 mg, 100 mg, 300 mg, 400 mg cap. Side effects Review of Systems complications in the use of drugs: viral, respiratory infections, To Keep Vein Open of the urinary system, ear, leukopenia, thrombocytopenia, anorexia, increased appetite, weight gain, blood glucose fluctuations in patients with diabetes; anxiety, emotional lability, depression, disturbance in thinking, agitation, hallucinations, drowsiness, dizziness, ataxia, seizures, hiperkineziya, dysarthria, amnesia, tremor, insomnia, headache, paresthesia, hiposteziya, breach of coordination, nystagmus, hypokinesia, other moving violations; impairment; vertyho, tinnitus, palpitations, hypertension, vasodilation; vomiting, nausea, abdominal pain, gingivitis, diarrhea, constipation, dry mouth, dyspepsia, impressions of teeth, swelling, hepatitis, jaundice, increased liver tests; AR, arthralgia, myalgia, back pain, muscle twitching, ACF, urinary incontinence, increase in breast, impotence.
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