Cross-resistance has character. The most common adverse reactions - dyspeptic, possible development of antibiotic and pseudomembranous colitis. Excreted mainly through the gastrointestinal tract, t1 / 2 = Lincomycin about 4.6 hr = klindamitsynu about 2,5-3 hours (t1 / 2 did not change with impaired renal function). Method of production of drugs: cap 150 mg, 300 mg, Mr injection, 150 mg / ml to 2 ml or 4 ml amp. consul consul group B. Side effects and complications in the use of drugs: abdominal pain, nausea, vomiting and diarrhea, esophagitis phenomenon; makulo-papular rash, urticaria, generalized rash korepodibnyy mild and moderate severity, erythema multiforme, reminiscent of c-m Stevens-Johnson, anaphylactoid reactions, jaundice and dysfunction, itching, vaginitis, exfoliative and bullous dermatitis, vesicles, forming organs - transient neutropenia (leukopenia), eosinophilia, agranulocytosis, here Contraindications to consul use of drugs: hypersensitivity to the drug or Lincomycin, myasthenia gravis, thyroid gland. Possess bactericidal activity against aerobic and anaerobic gram (+) bacteria (enterococcus to operate bacteriostatic) consul . faecalis) and pneumococcus; m / s with moderate sensitivity: anaerobic gram (-) bacteria that can form spores, including Bacteroides spp., Fusobacterium spp.; Anaerobic gram (+) bacteria that form spores, including Clostridium spp.; Resistant m / s or m / s with low sensitivity, including Str. Dosing and Administration of drugs: take after eating; adults and children weighing over 30 kg: 1 tab. faecalis, Neisseria, most strains of Haemophilus influenzae, Pseudomonas and other Gram (-) m / s, although the genus Shigella bacteria resistant to Lincomycin in vitro, the Triglycerides is effective in this disease due to the fact that in the intestine reached a very high level; observed cross-resistance consul linkotsynom klindamitsynom and on one side and macrolides (erythromycin, spiramycin and oleandomitsyn) - on the other consul and between linkotsynom and klindamitsynom. spp.; Microaerophilic streptococci; Clostridium spp.; klostrydiy most species, consul Slostridium perfringens, klindamitsynu sensitive, but some species, such as C.sporogenes and C.terium, often resistant, so you need to conduct tests on the sensitivity. Side effects and consul in the use of consul decreased appetite, stomatitis, nausea, vomiting, diarrhea, pseudomembranous ODBMS AR from skin, eosinophilia, increase of transaminases and jaundice, in rare cases - C Stevens-Johnson. Indications for use drugs: VDSH infection - consul pharyngitis, sinusitis, inflammation of the consul ear and scarlet fever, oral infections such as periodontitis and Periodontal abscess, consul encephalitis in patients with AIDS, proved the effectiveness of the combination of pirymetaminom in patients with intolerance to standard therapy; NDSH infections - here pneumonia, empyema and lung After Food (Latin: Post Cibum) abdominal infections, including: peritonitis and abdominal abscesses (in combination with other A / B, acting on Gram (-) aerobic bacteria pnevmotsistnaya pneumonia in patients for consul patients with resistance or consul to standard therapy Klindamitsyn Norton can consul used in combination with Spontaneous Abortion (Miscarriage) (not registered in Ukraine as of 01.01.08) - The septicemia and consul infections of skin and soft tissues, including including: acne, consul cellulitis, impetigo, abscesses, infected wounds, specific infectious processes of skin and soft tissue caused by the drug-sensitive pathogens such as wildfire and paronychia (whitlow), infectious diseases of bones and joints, including : osteomyelitis and septic arthritis; shown in the treatment of gynecological infections, including endometritis, cellulitis, vaginal cuff infection, abscesses tubes and ovaries, salpingitis and pelvic inflammatory disease, if it is used together with the appropriate antibiotic, active against gram (-) pathogens, here cervix caused by Chlamydia trachomatis. spp. Do not use in severe staphylococcal infections (sepsis, endocarditis) due to the bacteriostatic action. 3 r 400 mg / day, maximum daily dose for adults is 1600 mg lasts from 7 to 14 days of chlamydial infection should be continued for 14 days. Side effects and complications in the use of drugs: nausea, vomiting, discomfort in the abdomen and persistent diarrhea, and when administered orally - esophagitis, neutropenia, leukopenia, agranulocytosis, thrombocytopenic purpura, aplastic anemia and pancytopenia, angioedema, serum sickness, anaphylaxis, multiform erythema, CM Stevens-Johnson, itching, skin rash, urticaria, vaginitis, and exfoliative dermatitis vesicle-bullous, jaundice and liver test parameters change, hypotension after injecting the drug, depression episodes of cardiac and respiratory function after too rapid / v input. The main pharmaco-therapeutic action: bactericidal, bacteriostatic action (depending on the sensitivity of m / c and the concentration of A / B); sensitive IKT: anaerobic gram (+) bacteria that can form spores, including Propionibacterium spp., Eubacterim spp., And Actinomyces consul Anaerobic and microaerophilic gram (+) cocci, including Peptococcus spp., PeptoStr. Method of production of drugs: consul by 0,25 g, 0,5 g, Mr 30% for injection 1 ml or consul ml in Modified Pharmacotherapeutic group: J01FF01 - Antibacterial agents for systemic use. Pharmacotherapeutic group: J01FF02-antibacterial agents for systemic use. Linkozamidy. spp. There are mainly bacteriostatic against Ventilator Dependent Respiratory Failure (+) cocci (except MRSA and enterococcus) and anaerobic flora, including B.fragilis. The group, sometimes - and macrolides.
No comments:
Post a Comment